OryCalm®
Calms Inflammation and Rebuilds Skin’s Barrier
Read Time: 5 minutes
Hi everyone
For a long time, many in our industry assumed that calming an inflamed skin meant accepting trade-offs. Chronic redness and irritation were often managed with steroids or heavy occlusives, and we rarely expected a soothing ingredient to also help rebuild the skin.
OryCalm® – a new plant-made peptide – is proving that we can calm stressed skin and strengthen its barrier at the same time. This isn’t wishful thinking or “natural” fluff, but real biotech in action, with data to back it up. If you’ve been relying on old-school fixes for inflammation, OryCalm might just change your perspective.
OryCalm® is a biomimetic calming peptide grown in an unlikely farm – a rice field! Using an innovative method called Plant Molecular Farming, scientists at Transactiva produce this small protein inside common rice plants instead of a chemical reactor. The peptide is stored in rice grains (which naturally protect it), and after harvest it’s purified into a clean, water-based solution.
The final ingredient arrives as an easy-to-use liquid (INCI: Glycerin, Phosphate Buffered Saline, Hydrolysed Rice Protein, Phenoxyethanol) that blends smoothly into your formulations. No special tricks needed – it’s stable, 100% plant-derived, and effective even at low percentages (around 1% or less). In short, OryCalm gives you high-tech performance in a gentle, vegan-friendly format.
“Look deep into nature, and then you will understand everything better.”
– Albert Einstein
What does OryCalm do for skin?
Quite a lot, especially for sensitive, inflamed, or aging skin. In laboratory tests, OryCalm dialled down key inflammation signals – it reduced the release of ICAM-1 (a marker of skin inflammation) by about 37%, and lowered IL-1α levels in an irritated skin model. In other words, it doesn’t just mask redness; it helps turn off the inflammation at the source.
This biochemical calming translates into visible results. In a clinical study on irritated skin, OryCalm cut redness by 33% in just 30 minutes, and by 64% within 2 hours. That’s fast relief you can actually see. And it doesn’t stop there. The same study showed trans-epidermal water loss (TEWL) dropped by nearly 48% in 2 hours, meaning the skin’s barrier started holding in moisture almost twice as well, even while it was being soothed. By calming inflammation, OryCalm allows the skin’s barrier to recover and strengthen itself.
Users have reported that their skin not only feels calmer, but also smoother and more supple – with some even noticing reduced wrinkle depth after a period of use (confirmed by dermatological assessment). In short, OryCalm is suitable for even the most sensitive skin, yet it offers benefits that anyone – including those dealing with atopic eczema, acne-prone irritation, or early aging – can appreciate. And yes, it checks the green boxes too: Cosmos-compatible, vegan and non-GMO.
How and Where to Use OryCalm® in Formulations
Because OryCalm comes as an aqueous solution, it’s formulator-friendly and slots easily into all kinds of products. You won’t need high levels to see effects – a little goes a long way.
There is potential for fortifying your anti-inflammatory creams or redness-reducing serums with OryCalm for a quick calm-down effect and ongoing barrier support. It’s an excellent addition to sensitive-skin moisturisers where you want to minimise flare-ups and strengthen the skin over time. For delicate skin (think calming balms or gentle lotions), OryCalm provides soothing relief without any harsh chemicals.
Working on an anti-aging formula? Consider OryCalm as a secret weapon against “inflammaging” – it can calm micro-inflammation and help skin stay hydrated, which in turn softens the look of fine lines. It’s also perfect in barrier-repair creams or post-treatment recovery masks, helping stressed or compromised skin bounce back faster.
Whether it’s a lightweight hydrating serum, a calming night cream, or even a soothing sheet mask, OryCalm brings a dual action: immediate comfort and longer-term correction. In essence, you get to formulate with a calming-but-corrective active – one that doesn’t just placate the skin, but actively helps it become stronger and healthier.
LeanEase vs OryCalm
If you caught our last issue on LenEase®, you might be wondering: does OryCalm overlap with LenEase, or how are they different? It’s a great question – both are plant-made peptides aimed at soothing skin, but they have their own personalities.
LenEase® (from tobacco leaves) is like the rapid responder for acute sensitivity – it works within minutes to knock down redness and irritation fast. OryCalm® (from rice grain) also calms irritation, but shines in reinforcing the barrier and providing sustained relief over hours.
Think of LenEase as immediate first aid for flare-ups, while OryCalm is a gentle healer that not only calms but also helps the skin rebuild and defend against future stress. They can even complement each other in a regimen. So rather than duplicates, see them as two tools in your toolkit – one for quick soothing and one for deeper recovery.
Perhaps you’re also asking: Is a peptide grown in rice really reliable? It’s normal to be cautious with new technology, but rest assured – plant-grown actives can be just as potent and consistent as synthetic ones. In fact, Transactiva approaches these actives with pharma-grade rigor. The peptides are purified and tested thoroughly, with clinical studies backing their claims. “Plant-made” doesn’t mean “weak” or unproven – it means science has found a greener way to produce the molecule. OryCalm’s efficacy data (in vivo and in vitro) speaks for itself, and its quality is highly controlled. Plant Molecular Farming might sound futuristic, but it’s a well-established biotech method (even used in making vaccines) that delivers reliable results. So, you’re not taking a wild gamble; you’re adopting a cutting-edge ingredient that marries natural origins with scientific credibility.
Another concern could be: Is OryCalm only useful for inflammation? The good news is that by reducing chronic inflammation, OryCalm also addresses issues that go hand-in-hand with it. Reducing constant irritation allows the skin to repair its lipid barrier, hold more moisture, and even focus on renewal. Over time, this can translate to improvements in texture (think smoother, softer skin) and appearance (less blotchiness, potentially fewer fine lines). So, while OryCalm’s primary job is to calm, its long-term benefits – like stronger, healthier skin – set it apart from your typical one-dimensional soothing agent.
The Next-Gen Calming Active
To wrap up, let’s reinforce why OryCalm® deserves a spot in your formulation lineup. It’s a next generation calming peptide that works beyond the surface. Powered by rice and refined by biotech, OryCalm helps stressed skin repair itself, defend itself, and feel better fast. Few actives can claim to both instantly soothe and bolster the skin’s resilience the way OryCalm does. The result is relief for the end user (redness and discomfort fade away) and reassurance for you as a formulator that the skin is improving from within. All of this is supported by robust data, not hype – so you can speak to consumers and regulators with confidence about OryCalm’s effects.
In a world where consumers seek gentle, clean, yet effective solutions, OryCalm hits the trifecta: it’s gentle and plant-derived, it’s clinically proven, and it addresses one of the beauty world’s big challenges (chronic inflammation) at its root. It truly is a calming revolution in a rice grain.
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So, there you have it…
We hope this introduction to OryCalm® sparks some ideas for your next project. We’d love to hear from you – feel free to reply with any questions about OryCalm, ask for the full data pack or clinical results, or even request a sample to test in your lab.
At the end of the day, our goal is to support you in crafting products that make a real difference. OryCalm® is one exciting tool to do just that.
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Thanks for reading, and see you next week.
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